Slay the Spider Queen is the sixth mission unlocked in the Stalker tier of missions at level 44.

This mission requires 45 energy as well as three Claws of the Demon, four Shadow Manipulation, and two Cause Madness abilities.

On completion, it provides between 2,500,000 and 4,000,000 blood and 60 experience points. Completing the mission will sometimes provide a rare ability, Blood Shield.

Each time the mission is completed, mission mastery increases by 7% for Mastery Level 1, 6% for Mastery Level 2, and 5% for Mastery Level 3.

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